ea0086p100 | Neuroendocrinology and Pituitary | SFEBES2022
Livia Gheorghiu Monica
, Maria Prunariu Ana
, Maria Lider Burciulescu Sofia
, Purice Mariana
, Iordachescu Carmen
Introduction: Excess GH in acromegaly has lipolytic action and detrimental effect on glucose metabolism and insulin signaling. Recent studies have suggested a specific lipodystrophy in patients with acromegaly. Paradoxically, although the visceral adipose tissue (VAT) and intrahepatic lipid were reduced in active acromegaly compared to controls, insulin resistance was increased. Fat was redistributed from subcutaneous and visceral depots to muscle; weight and VAT depots rose w...